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Which common treatment method for hyperthyroidism will lower a patient's risk for cardiovascular disease? Authors of a new study sought to find out.
Reference: Essi R, Saara M, Heini H, et al. Cardiovascular morbidity and mortality after treatment of hyperthyroidism with either radioactive iodine or thyroidectomy. Thyroid. 2018;28:1111-1120.Â
Ryödi Essi, MD, and fellow researchers in Finland have found that thyroidectomy for hyperthyroidism conveys a lower risk for cardiovascular disease (CVD) than radioactive iodine (RAI) treatment with a state of hypothyroidism predicting the lowest risk of subsequent CVD. Click through the slides for details on their study and take home points for clinical practice.
Hyperthyroidism and CVD. While it is known that hyperthyroidism is associated with an increased risk of CV morbidity and mortality, it is unclear how CV morbidity before and after treatment with RAI or a thryoidectomy is affected by each treatment. Authors of this study sought to determine the impact of both treatment modalities (RAI and thyroidectomy) and treatment outcome on CV morbidity and mortality after treatment.
The Study. This retrospective, register-based study looked at 6148 hyperthyroid patients treated with either RAI or thyroidectomy and 18 432 matched control subjects that were compared to research subjects. Discharge diagnoses were classified into 10 major subgroups based on CV diagnostic codes and follow-up ended on the date of the first hospitalization due to CVD, date of death, emigration, or common closing date.
The Results:
Results (continued):
Take Home Points: