Nephrology

The Endocrinology Network® nephrology clinical resource center is our hub for the latest in news and developments related to nephrology and renal impairment from the perspective of an endocrinologist. Be sure to check back often for the latest in nephrology and CKD.

Initial eGFR Dips Common with SGLT2 Inhibitors, Not Typically Associated with Negative Outcomes

April 25, 2022

An analysis of the DAPA-HF trial provides insight into the occurrence of eGFR dips in the first 14 days following initiation of therapy with an SGLT2 inhibitor and their association with long-term outcomes.

Finerenone Reduces CV Risk in T2D and CKD, Regardless of ASCVD History

April 07, 2022

A prespecified analysis of FIDELITY details the effects of finerenone against placebo therapy for reducing the risk of cardiovascular events based on history of ASCVD among patients with type 2 diabetes and chronic kidney disease.

Endocrinology Month in Review: March 2022

March 26, 2022

Each month, our editorial staff compiles a month in review highlighting the most popular content from the past month. March's month in review features CGM news, calls for insulin co-pay caps, and info on the declining quality of US diets.

GLP-1 RAs Could Lower Mortality Risk in Type 2 Diabetes with Advanced CKD

March 08, 2022

A retrospective cohort study suggests use of GLP-1 RAs was associated with a 21% reduction in risk of all-cause mortality in patients with type 2 diabetes and advanced-stage chronic kidney disease compared with DPP-4 inhibitors.

Bardoxolone Rejected by FDA for CKD Caused by Alport Syndrome

February 26, 2022

Announced by Reata Pharmaceuticals on February 25, the Complete Response Letter from the FDA for bardoxolone methyl comes a little over 2 months after an FDA advisory committee voted unanimously against approval of the once-daily, orally administered activator of Nrf2.

Infertility Treatments Could Raise Risk of Acute Kidney Injury, Heart Rhythm Disorders

February 25, 2022

New research suggests pregnancies conceived with assisted reproductive technology were associated with a more than doubling in risk for acute kidney injury.

Study Details Causal Effect of Obesity on Diabetic Nephropathy

February 22, 2022

Data from an analysis of more than 150,000 patients suggests increased BMI was associated with more than a 3-fold increase in odds of diabetic nephropathy in patients with type 2 diabetes, but this effect was more apparent in women who experienced a 14-fold increase in odds of diabetic nephropathy.