Highlights include obstructive sleep apnea as a factor for T2DM; a test that distinguishes between T1DM and T2DM; and missed opportunities in diabetes prevention.
The highlights of 3 new studies in type 2 diabetes mellitus (T2DM) include: men with obstructive sleep apnea (OSA) secrete more insulin vs women and as a result have a higher risk of T2DM; a novel test that rapidly distinguishes between type 1 diabetes mellitus (T1DM) and T2DM; and many women with glucose intolerance in pregnancy are not assessed for T2DM after giving birth.
Men with OSA at Greater Risk of T2DM vs Women. Study sought to determine if there are sex differences in the impact of OSA on glucose metabolism in nondiabetic, obese adults.
Author's Insights. Study found that men with OSA had significantly higher fasting glucose, 1-hour glucose levels, glucose AUC, and AUC for insulin secretion rate vs women with OSA, but both genders had similar 2-hour glucose levels. Also, men with OSA had significantly worse beta cell function vs women with OSA.
For more information: Temple KA, Leproult R, Morselli L, et al. Sex differences in the impact of obstructive sleep apnea on glucose metabolism. Front Endocrinol. 2018;9:376.
New Test Differentiates T1DM and T2DM. Authors of a new study aimed to find out if a genetic risk array could serve as a clinical tool to differentiate between T1DM and T2DM.
Author's Insights. Using the Biochip Array Technology, an examination of 259 samples (2590 genotypes) were in agreement with predicted genotypes. The samples tested covered all of the genotypes linked to 10 single nucleotide polymorphisms associated with T1DM.
For more information: Yadef R, Latten MJ, Murray HA, et al. Development of a type I diabetes genetic risk array. Paper presented at: 70th American Association for Clinical Chemistry Annual Scientific Meeting & Clinical Lab Expo; August 2018; Chicago, IL.
Missed Opportunities in T2DM Prevention. The retrospective study identified 142 women with gestational or overt diabetes to examine the post-natal care, prevalence of postpartum glucose testing, and the factors associated with testing.
Author's Insights. Study results showed that OGTT and random glucose testing at 6 weeks post delivery for women diagnosed with gestational or overt diabetes is very low, therefore, there are missed opportunities for assessing and preventing diabetes in women.
For more information: Imoh LC, Selowo TT, Lukden SM. Post-partum glucose testing: Missed opportunities for assessing and preventing diabetes mellitus in women with glucose intolerance in pregnancy. Paper presented at: 70th American Association for Clinical Chemistry Annual Scientific Meeting & Clinical Lab Expo; August 2018; Chicago, IL.