Answer: B. False
GH replacement dose calculated for adults based on body weight has led to a high frequency of adverse side effects, related primarily to fluid retention (eg, paresthesias, joint stiffness, myalgia). Instead, initiation in adults is with low doses followed by gradual uptitration to reach normal IGF-1 levels.
6. Which of the following is/are known health benefits of GHRT in AGHD?
A. Increased exercise capacity
B. Lower diastolic blood pressure
C. Improved total cholesterol
D. Increased bone mass
E. A and B
F. B and C
G. All the above
- Boguszewski CL. Update on GH therapy in adults. F1000Res. 2017; doi:10.12688/f1000research.12057.1.
- Molitch ME, Clemmons DR, Malozowski S, et al. Evaluation and treatment of adult growth hormone deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96:1587–609. 10.1210/jc.2011-0179