Impact of Ethnicity, Gender on Skin Autoflourescence and Risk for CV, DM

October 13, 2017

A new study evaluates the impact of ethnicity on skin autoflourescence used to measure accumulation of atherogenic glycated proteins.

Advanced glycation end products (AGEs) are the result of protein or lipid exposure to sugars. AGEs are known to be prevalent in the vasculature of patients with diabetes and to contribute to the development of cardiovascular disease and neurodegenerative disorders.1,2 Some species of AGEs naturally exhibit fluorescence and techniques to measure skin autoflourescence (SAF) have been developed as potential noninvase tools to estimate AGE accumulation in human skin. The majority of SAF-based reference values have been developed using Caucasian/Asian populations.3,4The study highlighted in the short slide show above examines ethnicity- and gender-specific differences in SAF.

References:

1. Vélayoudom-Céphise FL, et al. Skin autofluorescence predicts cardio-renal outcome in type 1 diabetes: a longitudinal study. Cardiovasc Diabetol. 2016;15:1272. Sugisawa E, Miura J, Iwamoto Y, Uchigata Y. Skin autofluorescence reflects integration of past long-term glycemic control in patients with type 1 diabetes. Diabetes Care. 2013;36: 2339–2345. pmid:235791773. Koetsier M, Lutgers HL, de Jonge C, Links TP, Smit AJ, Graaff R. Reference values of skin autoflourescence. Diabetes Technol Ther. 2010;12:399–403. pmid:20388050 4. Yue X, Hu H, Koetsier M, Graaff R, Han C. Reference values for the Chinese population of skin autofluorescence as a marker of advanced glycation end products accumulated in tissue. Diabet Med. 2011;28:818–823. pmid:21204956 5. Ahmad MS, Kimhofer T, Ahmad S, et al. Ethnicity and skin autofluorescence-based risk-engines for cardiovascular disease and diabetes mellitus. PLoS One. 2017 Sep 20;12(9):e0185175. doi: 10.1371/journal.pone.0185175.