Endo News Roundup: Hypoglycemia Research

April 3, 2018

A patch that can detect early symptoms of hypoglycemia is one of three studies discussed in this month's endocrinology news roundup.

New studies in hypoglycemic research highlight the use of a biosensor patch that can detect early symptoms of hypoglycemia; brain scans that show how T1DM patients can fail to recognize hypoglycemia clues; and beta cell implants that normalize glucose levels in mice with T1DM.Â

Endo News Roundup for April 2018 - Hypoglycemia Research

Biosensor Patch Detects Early Symptoms of Hypoglycemia

Heart Rate Variability Offers Clues. Study examined the efficacy of the VitalConnect HealthPatch on hypoglycemia detection.

Clinical Implications. Study found that the patch detected clear patterns of change in heart rate variability at the start of hypoglycemia.

For more information, check out the full article: Olde Bekkink M, et. al. Early Detection Of Hypoglycemia In Type 1 Diabetes Using A Wearable Device Measuring Heart Rate Variability. Paper presented at: ENDO 2018; March 2018; Chicago, IL.

Brain Scans Show Some with T1DM Miss Hypoglycemia Cues

Diminishing Brain Response. Study examined brain responses to drops in blood glucose levels in both healthy indviduals and T1DM patients.

Clinical Implications. Study found that there was a loss of coordinated brain response to a decline in blood sugar in T1DM patients and the first areas in the brain to weaken were linked to regulated feeding behavior.

For more information, check out the full article: Hwang JJ, et. al. Hypoglycemia unawareness in type 1 diabetes suppresses brain responses to hypoglycemia. J Clin Invest. 2018;128:1485-1495

Beta Cell Implantation May Alleviate Type 1 DM

Healthy Beta Cells Normalized Glucose Levels in T1DM Mice. Study aimed to examine how novel subcutaneous implantation of insulin-producing beta cells affected blood glucose levels in mice.

Clinical Implications. Study found that the mice who were treated with the beta cells had normalized glucose levels and increased survival versus the untreated mice.

For more information, check out the full article: Elizondo DM, et. al. Implantation of a Novel Biomaterial Seeded with Beta-Cells Restores Insulin and Normalizes Glucose Levels in a Model of Type 1 Diabetes. Paper presented at: ENDO 2018; March 2018; Chicago, IL.