Evidence is mounting that links insulin deficiency and insulin resistance to mediation of Alzheimer disease-type neurodegeneration. Get the highlights in these 9 slides.
Brain Insulin Resistance Linked to Overeating, Altered Homeostatic Setpoint
A new study found that in obese college students with significant visceral fat, specific brain regions became insulin-resistant.
I'm a DO--And My Day Job Is Teaching
“Doctor” comes from the Latin docēre, “to teach.”
What Impact of Weight on GLP-1-stimulated Insulin Secretion?
The size of the incretin effect among healthy subjects may vary up to 2-fold, suggesting differences in ß-cell sensitivity to GLP-1. Does BMI play a role in this variability?
A New Combination Proves Itself in Treatment for Type 2 Diabetes
Try your hand at this first in a series of questions on combination drug therapy to optimize treatment of T2DM.
At 4 Years, Dapagliflozin Bests Glipizide as Add-on to Metformin
This extension trial is the longest to track efficacy/tolerability of a novel vs more traditional agent as add-on therapy for uncontrolled type 2 diabetes.
Adherence to GLP-1 Therapy Yields Better A1c Outcomes, Higher Costs
Adherent patients were more likely to achieve at least a 1.0% drop in A1c; half achieved the ADA-prescribed goal of <7%. Higher cost was not a surprise.
An Older Woman at A1c Goal with Asymptomatic Hypoglycemia: What Next?
RM is an active 78-year-old woman with no complaints about her health or her medications. Then she tells you about her home blood glucose readings.
GLP-1 Receptor Agonists Go Head-to-Head
This short slide show summarizes results of 8 phase III clinical trials, revealing favorable class efficacy and also differences that should be considered before treatment selection.
SGLT2 Inhibitors and Fracture Risk: A Review of What We Know
It's probably too early to pass judgment but data from clinical trials point to decreased bone mineral density and increased treatment-emergent fractures in patients taking the new antidiabetes drugs.
Albiglutide Effective in Triple Therapy for Uncontrolled Type 2 Diabetes
In obese patients with type 2 diabetes uncontrolled by lifestyle and two oral agents, albiglutide significantly lowered A1c as part of 3-drug therapy.
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