SGLT2 Inhibitors: Basic Training Quiz

SGLT2 inhibitors haven’t been available for long, but EndocrinologyNetwork.com has covered the basics in our SGLT2 topic center. See how you fare on our 6-question Basic Training Quiz. Links at the end will take you to articles on the pros, the cons, and more on this new class of antidiabetes drugs.

1. Which of the following is NOT a primary advantage of treatment with SGLT2 inhibitors?

A. Neutral impact on hypoglycemia

B. Modest weight loss

C. Improved glycemia, A1c reductions (0.6% - 1%)

D. Insulin-independent action

E. Mild reduction in blood pressure

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Answer: A. Neutral impact on hypoglycemia

2. SGLT2 inhibitors block the SGLT2 protein involved in what percentage of glucose reabsorption in the proximal renal tubule?

A. 50%

B. 70%

C. 80%

D. 90%

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Answer: D. 90%

3. SGLT2 inhibitors are associated with a reduction in blood pressure of approximately:

A. 1% to 3%

B. 3% to 5%

C. 5% to 7%

D. 7% to 9%

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Answer: B. 3% to 5%

4. As a result of their glucose-independent mechanism of action, SGLT2 inhibitors do not depend on level of β-cell function and are effective at all stages of disease.  

A. True

B. False

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Answer: A. True

5. The FDA requires manufacturers of SGLT2 inhibitors to conduct post-marketing studies and pharmacovigilance programs to learn more about:

A. Bladder cancer risk

B. Cardiovascular outcomes

C. Renal development (animal studies)

D. Pediatric safety/efficacy (bone health/development)

E. All of the above

F. A and B only

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Answer: E. All of the above

6. In patients with an estimated glomerular filtration rate (eGFR) of between 45 and 60 mL/min/1.73m²,  which of the following is FALSE:

A. There is no dosage adjustment required for the 3 FDA-approved SGLT2 inhibitors at the 2 dosage strengths available for each

B. Canagliflozin and empagliflozin may only be dosed at the lower of the 2 strengths for each (100 mg and 10 mg, respectively)

C. Dapagliflozin is not recommended in patients with an eGFR <60 mL/min/1.73m²

D. Empagliflozin not recommended in patients with an eGFR <60 mL/min/1.73m²

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Answer: A. There is no dosage adjustment required for the 3 FDA-approved SGLT2 inhibitors at the 2 dosage strengths available for each

The following articles from the EndocrinologyNetwork SGLT2 Topic Center provide more detailed information on all of the quiz questions and answers:

SGLT2 Inhibitors: Mechanism of Action, Pros, and Cons

SGLT2 Inhibitors: Pros, Cons, Comparisons, and Considerations

SGLT2 Inhibitors: 5 Things You Should Know

SGLT2 Inhibitors: 4 Points on Efficacy, Safety You Need to Know

Thank you for testing your SGLT2 knowledge. Please leave us a comment on the quiz, other material you would like to see included on EndocrinologyNetwork.com, or any thing else. -The Editors