Left Ventricular Diastolic Function Linked with Poor Glycemic Control
A new study found that left ventricular diastolic function is linked to poor glycemic control and A1c in T2DM patients.
Reference:Â Clarke GD, Molina-Wilkins M, Solis-Herrera C, et al. Impaired left ventricular diastolicfunction in T2DM patients is closely related to glycemic control. Endocrinol Diab Metab. 2018;1:e14.Â
Geoffrey Clarke, PhD, and fellow researchers in San Antonio, Texas have found that left ventricular diastolic function (LVDF) is inversely related to plasma glucose and A1c in patients with type 2 diabetes (T2DM). Click through the slides above for study details and take home points for physicians.
Heart Function and Diabetes. Authors of the new study used TTE and CMRI to evaluate the relationship between diastolic function and glycemic control in T2DM patients.
The Study. Authors conducted a prospective comparison of 19 T2DM patients to 21 matched NGT control subjects with normal echocardiograms. TTE and CMRI were performed to determine left ventricular diastolic parameters and classify any present diastolic dysfunction.
Results. At baseline, all subjects had either normal or mildly impaired LVDF. Left ventricular systolic functional measurements by TTE and CMRI were not significantly different between T2DM and NGT groups and were within normal range. Also, measures of diastolic function by both TTE and CMRI significantly decreased in T2DM vs NGT subjects. The E/A ratio by CMRI and TTE significantly and negatively correlated with A1c (Ï= −.61, P=0.00003) and fasting plasma glucose (r= −.60, P=0.00004).
Take Home Points:
- Well-controlled T2DM patients manifest evidence of impaired LVDF despite normal LV systolic function
- Impaired LVDF was associated with glycemic level as determined by A1c and fasting plasma glucose concentration
- Consider LVDF among previously characterized CV sequelae of T2DM with prevention being the focus of treatment