At-a-Glance: Studies you may find of interest look at AFib in T1DM, new fracture risk data, obesity outcomes, and more.
Click through the slides above for our monthly at-a-glance reviews of recent studies in endocrinology. Among our September topics:
• Risk of atrial fibrillation in patients with T1DM
• Novel predictors of postmenopausal fracture
• Clinical implications of weight variability
Risk of Atrial Fibrillation in People With Type 1 Diabetes Compared With Matched Controls From the General Population: A Prospective Case-Control Study
• A large Swedish study found that over a 10-year period women with T1DM had a 50% increased risk of atrial fibrillation; men had only a slightly elevated risk.
• The risk of atrial fibrillation was higher among both women and men who had worse glycemic control and renal complications.
Sleep in Children With Type 1 Diabetes and Their Parents in the T1D Exchange
• In a recent survey, parents of children aged 2 to 12 years with T1DM reported that 67% of these children met the criteria for poor sleep quality.
• Poor sleep quality was associated with worse glycemic control, severe hypoglycemia, diabetic ketoacidosis, poor parental sleep quality and well-being, and fear of hypoglycemia.
Serum Levels of a Cathepsin-K Generated Periostin Fragment Predict Incident Low-Trauma Fractures in Postmenopausal Women Independently of BMD and FRAX
• In postmenopausal women, circulating serum levels of the biomarker K-Postn (periostin fragment resulting from cathepsin-K digestion) are correlated with the risk of low-trauma clinical fracture.
• This risk is independent of bone mineral density, bone turnover markers, and results of the Fracture Risk Assessment Tool.
Determinants of Short Term Fracture Risk in Patients With a Recent History of Low-Trauma Non-Vertebral Fracture
• Risk factors for a second low-trauma non-vertebral fracture (NVF) within 3 years of a previous one were a history of a fall in the past year, a history of a severe low-trauma NVF, and a BMI of less than 20.
• Age older than 78 years protected against the risk of another NVF.
Variability in Weight Change Early in Behavioral Weight Loss Treatment: Theoretical and Clinical Implications
• Participants in a yearlong behavioral weight loss program who had greater weight variability during the first 6 and 12 weeks of the program subsequently had less weight loss after 12 months and at 24-month follow-up.
• The association between weight variability and weight change at 6 months was stronger in men than in women.
Early Pregnancy Weight Gain Exerts the Strongest Effect on Birth Weight, Posing a Critical Time to Prevent Childhood Obesity
• Excessive weight gain early in pregnancy (before 24 weeks) was associated with an elevated risk of having an infant who was large for gestational age.
• The impact on infant size of weight gain during early pregnancy was independent of pre-pregnancy body mass index and later gestational weight gain.