Insulin 2016: Year-End News Roundup

In honor Frederick G. Banting’s birth 125 years ago today, we present a review of developments in insulin for the year 2016.

Obese Patients with Type 2 Diabetes on Conventional Versus Intensive Insulin Therapy: Efficacy of Low-Calorie Dietary Intervention. Abstract link.****BeAM Value: an Indicator of the Need to Initiate and Intensify Prandial Therapy in Patients with Type 2 Diabetes Mellitus Receiving Basal Insulin. Abstract Link. See also: Targeting Insulin Doses in Type 2 Diabetes.

Major Adverse Cardiovascular Events with Basal Insulin Peglispro versus Comparator Insulins in Patients with Type 1 or Type 2 Diabetes: a Meta-Analysis. Abstract Link. See also: Cardiovascular Risks with Insulins. ****Comparing the Clinical Outcomes Between Insulin-treated and Non-insulin-treated Patients with Type 2 Diabetes Mellitus after Coronary Artery Bypass Surgery: a Systematic Review and Meta-Analysis. Abstract link.

FDA Approves First Automated Insulin Delivery Device for Type 1 Diabetes. Press release. ****Closed-Loop Insulin Delivery during Pregnancy in Women with Type 1 Diabetes Abstract link.

FDA Approves a Dedicated Syringe to be Used with Humulin R U-500 Insulin. Abstract link. ****FDA Approves Basaglar, the First “Follow-on” Insulin Glargine Product to Treat Diabetes. Press release.

Diabetes Technology-Continuous Subcutaneous Insulin Infusion Therapy and Continuous Glucose Monitoring in Adults: an Endocrine Society Clinical Practice Guideline. Abstract link. See also: New Diabetes Guidelines: Insulin Pumps & CGM. ****Optimized Mealtime Insulin Dosing for Fat and Protein in Type 1 Diabetes: Application of a Model-Based Approach to Derive Insulin Doses for Open-Loop Diabetes Management. Abstract link. See also: Rethink Optimal Insulin Dose Calculations.

Insulin Prices Soar While Drugmakers’ Share Stays Flat. Abstract link. See also: Cost Analysis: Insulin & Other Antihyperglycemics. ****Bernie Sanders Requests Federal Investigation of Insulin Makers for Price Collusion. Abstract Link. ****

Formulation of Insulin for Oral Dosing. Abstract link. See also New Formulation to Deliver Insulin Orally. ****Determining Starting Basal Rates of Insulin Infusion for Insulin Pump Users: a Comparison between Methods. Abstract link. See also: Starting Insulin Rates in Pump Users.

Biosimilars and New Insulin Versions. Abstract Link. See also: New Insulin Versions on the Horizon.**** Construction of Insulin 18-mer Nanoassemblies Driven by Coordination to Iron(II) and Zinc(II) Ions at Distinct Sites. Abstract link. See also: One Step Closer to Designer Insulin.

Potential Diabetes Treatment Uses Light-Activated Gel to Release Insulin. Abstract link. ****Efficacy and Safety of Oral Insulin Compared to Subcutaneous Insulin: a Systematic Review and Meta-Analysis. Abstract link.