Do You Speak DPP-4I?

Dipeptidyl peptidase-4 inhibitors (DPP-4Is) have been in the type 2 diabetes tool box since 2006. They are associated with a modest decrease in A1c and a mostly neutral impact on weight. There are currently four approved agents in the US and there are also five approved agents that combine a DPP-4I with metformin and one that combines a DPP-4I and a thiazolidinedione.

How well versed are you in the language of DPP-4I? Find out in 5 short questions.

1. Which one of the following DPP-4I combination drugs does NOT contain metformin:

A. Tradjenta

B. Kombiglyze

C. Kazano

D. Jentadueto

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Answer: A. Tradjenta

Tradjenta is the DPP-4I linagliptin

2. The DPP-4I combination drug that contains a thiazolidinedione is:

A. Nesina

B. Trulicity

C. Oseni

D. Onglyza

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Answer: C. Oseni

Oseni combines alogliptin and pioglitazone; Nesina is alogliptin; Trulicity is dulaglutide; Onglyza is saxagliptin

3.Kazano combines metformin with which of the following DPP-4Is?

A. Linagliptin

B. Sitagliptin

C. Saxagliptin

D. Alogliptin

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Answer D. Alogliptin

4. Januvia is the brand name for which of the following generic DPP-4Is?

A. Alogliptin

B. Linagliptin

C. Sitagliptin

D. Saxagliptin

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Answer: D. Sitagliptin

5. Jentadueto is the brand name for the combination of saxagliptin and metformin.

A. True

B. False

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Anwer:  B. False

Jentadueto is linagliptin and metformin

Table. DPP-4Is, DPP-4I Combinations, GLP-1 Receptor Agonists

Generic

Brand

Generic

Brand

Sitagliptin

Januvia

Saxagliptin/metformin

Kombiglyze

Saxagliptin

Onglyza

Alogliptin/metformin

Kazano

Linagliptin

Tradjenta

Alogliptin/pioglitazone

Oseni

Alogliptin

Nesina

Exenatide (GLP-1)

Byetta

Sitagliptin/metformin

Janumet/Janumet XR

Exanatide (GLP-1)

Bydureon

Linagliptin/metformin

Jentadueto

Dulaglutide (GLP-1)

Trulicity