Treatment results tend to plateau
Eight studies examined the effect of GHR therapy on HR-QoL, with results showing an improvement in QoL-AGHDA scores of 2.3 and 5.3 points. The QoL-AGHDA scale includes 25 statements responded to with “Yes” or “No.” A score can range from 0 to 25 with higher scores indicating poor QoL. In 2 studies, issues that were least impaired improved first such as socialization issues, tenseness, and self-confidence, while tiredness, and memory and concentration were among the last symptoms to improve.
Short-term improvement in QoL was seen in 4 studies, with tiredness, memory and concentration improving after 1 year; results tended to plateau after the first year and in the long-term, improvement was dependent upon factors such as European origin, lack of depression history, lower body mass index, and no impaired vision at baseline.
… results tended to plateau after the first year and in the long-term, improvement was dependent upon factors such as European origin, lack of depression history, lower body mass index, and no impaired vision at baseline.
With regard to the health economic impact of AGHD treatment, economic burden was associated with “productivity losses related to the disease” such as lower working capacity related to days off for sickness and a higher unemployment rate. After successful GHR therapy, patient productivity is substantially improved and so economic loss is reduced. Specific improvements noted in one study after 12 months of GHR therapy included increased physical activity and decreased need for assistance with activities of daily living; these measures correlated with improved Qol, as measured by QoL-AGHDA, and a reduction in the number of sick days from work, visits to a doctor, hospital stays, and use of healthcare resources.
The authors conclude that the results of their review underscore the need for additional research that will help optimize patient management and outcomes, particularly given the increasing need to better manage health care resources.
Source: Loftus J, Camacho-Hubner C, Hey-Hadavi J, et al. Targeted literature review of the humanistic and economic burden of adult growth hormone deficiency. Curr Med Res Opin. 2018 Nov 9.