Answer: E. All of the above. GH replacement therapy has been associated with a decrease in fat mass and an increase in lean body mass, including tissue hydration and skeletal muscle mass. The current review cites a recent meta-analysis of 22 trials that found an increase in lean body mass of 2.61 kg in GH-treated subjects vs 0.04 in the placebo group; fat mass declined by 2.19 kg (GH) vs 0.31 kg (placebo). The observed changes were dose-related.
Díez JJ, Sangiao-Alvarellos S, Cordido F. Treatment with growth hormone for adults with growth hormone deficiency: benefits and risks. Int J Mol Sci. 2018;19:893.